RUN & SH3 domain-containing protein 1 (new molecule containing SH3 at the carboxy-terminus, Nesca, RUSC1, NESCA)

Function

• putative signaling adapter
• role in neuronal differentiation
• role in regulation of NGF-dependent neurite outgrowth
• role in signaling pathways regulated by prolonged activation of MAPK (putative)
• phosphorylated on Ser following nuclear translocation

Structure

• RUN domain is necessary for NGF induced nuclear redistribution
• contains 1 RUN domain
• contains 1 SH3 domain

Compartment

• cytoplasm, nucleus
• translocated to nuclear envelope upon stimulation with NGF

Alternative splicing

named isoforms=2

Expression

predominantly expressed in brain

More general terms

• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9BVN2.html