Rab9 effector protein with Kelch motifs (40 kD Rab9 effector protein, p40, RABEPK, RAB9P40)

Function

• Rab9 effector required for endosome to trans-Golgi network transport
• interacts with PIP5K3, subsequently phosphorylated
• phosphorylated on Ser residues most probably by PIP5K3
• interacts with RAB9 in its GTP-bound conformation

Structure

contains 5 Kelch repeats

Compartment

• cytoplasm, endosome membrane interaction with PIP5K3 & subsequent phosphorylation recruits it to endosomal membrane

Alternative splicing

named isoforms=2

More general terms

• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/605962
• UniProt: http://www.uniprot.org/uniprot/Q7Z6M1.html