FAS-associated factor 1 (Protein FAF1, hFAF1, FAF1)

Function

• potentiates but cannot initiate FAS-induced apoptosis
• specifically interacts with cytoplasmic domain of FAS

Structure

contains 1 UBX domain

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

• expressed in testis > skeletal muscle, heart > prostate, thymus, ovary, small intestine, colon
• not detected in peripheral blood leukocytes

More general terms

• nuclear protein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/604460
• UniProt: http://www.uniprot.org/uniprot/Q9UNN5.html