ataxin-2-like protein (ataxin-2 domain protein, ataxin-2-related protein, ATXN2L, A2D, A2LG, A2LP, A2RP)

Function

• interacts with MPL/TPOR & EPOR & dissociates after ligand stimulation
• thrombopoietin triggers the phosphorylation on Tyr (dependent on MPL C-terminal domain)

Structure

• Arg-361 is dimethylated, probably to asymmetric dimethylarginine

Compartment

peripheral membrane

Alternative splicing

named isoforms=7

Expression

• expressed in thymus, lymph node, spleen, fetal kidney, adult testis
• constitutively expresses with MPL & EPOR in hematopoietic cells

More general terms

• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/607931
• UniProt: http://www.uniprot.org/uniprot/Q8WWM7.html