poly(rC)-binding protein 1 (alpha-CP1, hnRNP-E1, nucleic acid-binding protein SUB2.3, PCBP1)

Function

• single-stranded nucleic acid binding protein
• binds preferentially to oligo dC
• phosphorylation lowers poly(rC)-binding activity

Structure

• contains 3 KH domains

Compartment

• nucleus, cytoplasm
• may shuttle between the nucleus & the cytoplasm

Expression

• expressed in skeletal muscle, thymus, peripheral blood leucocytes > prostate, spleen, testis, ovary, small intestine, heart, liver, adrenal, thyroid

More general terms

• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/601209
• UniProt: http://www.uniprot.org/uniprot/Q15365.html