transcription elongation factor A protein-like 1 (TCEA-like protein 1, transcription elongation factor S-II protein-like 1, nuclear phosphoprotein p21/SIIR, TCEAL1, SIIR)

Function

• transcriptional regulation (putative)
• modulates various viral & cellular promoters
  • transcription from the FOS promoter is increased
  • Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter activity is repressed
• phosphorylation of Ser-36 & Ser-37 implicated in transcriptional repression
• does not bind DNA directly

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

• ubiquitously expressed, including heart, ovary, prostate, skeletal muscle > brain, placenta, testis, small intestine > lung, liver, spleen

Pathology

• expressed in several cancer cell lines

More general terms

• transcription elongation factor A protein-like
• phosphoprotein

Additional terms

• transcription elongation factor A

Database

• OMIM: https://mirror.omim.org/entry/300237
• UniProt: http://www.uniprot.org/uniprot/Q15170.html