general vesicular transport factor p115; transcytosis-associated protein; TAP; vesicle docking protein (USO1, VDP)

Function

• general vesicular transport factor
• intercisternal transport in the Golgi stack
• transcytotic fusion &/or subsequent binding of vesicles to target membrane
• vesicular anchor holding vesicular & target membranes in proximity (putative)
• phosphorylated in a cell cycle-specific manner
  • phosphorylated in interphase but not in mitotic cells
  • dephosphorylated protein associates with Golgi membrane
  • phosphorylation promotes dissociation

Structure

• globular head
• elongated tail (coiled-coil)
• highly acidic C-terminal domain

Compartment

• cytoplasm, Golgi, peripheral membrane
• recycles between cytosol & Golgi during interphase

More general terms

• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/603344
• UniProt: http://www.uniprot.org/uniprot/O60763.html