down-regulated in metastasis protein; small subunit processome component 20 homolog; novel nucleolar protein 73; NNP73; protein key-1A6 (UTP20 DRIM)

Function

• role in 18S pre-rRNA processing
• associates with U3 snoRNA
• interacts with FBL & PPP1R26

Structure

• belongs to the UTP20 family
• contains 2 HEAT repeats

Compartment

• nucleus, nucleolus
• colocalizes with NCL in the nucleolus

Expression

• expressed in appendix, brain, colon, fetal liver, heart, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, spleen, testis & thymus

More general terms

• phosphoprotein
• nuclear protein
• HEAT repeat-containing protein (HEATR)

Additional terms

• metastasis

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=27340
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:27340
• OMIM: https://mirror.omim.org/entry/612822
• UniProt: http://www.uniprot.org/uniprot/O75691.html