Golgin subfamily A member 4; 256 kD golgin; Golgin-245; protein 72.1; trans-Golgi p230 (GOLGA4)

Function

• may play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1
• interacts with ARL1 with bound GTP
• interacts with MACF1

Structure

• homodimer
• extended rod-like protein with coiled-coil domains
• contains 1 GRIP domain

Compartment

• cytoplasm
• Golgi membrane

Alternative splicing

• named isoforms=3
• additional isoforms seem to exist

Pathology

• antibodies against GOLGA4 are found in sera from patients with Sjogren's syndrome & hepatitis B

More general terms

• Golgin subfamily A (GOLGA)
• phosphoprotein

Additional terms

• hepatitis B infection
• Sjogren's syndrome (autoimmune epitheliitis)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2803
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2803
• OMIM: https://mirror.omim.org/entry/602509
• UniProt: http://www.uniprot.org/uniprot/Q13439.html