solute carrier family 20 member 1 (SLC20A11, sodium-dependent phosphate transporter 1, phosphate transporter 1, PiT-1, gibbon ape leukemia virus receptor 1, GLVR-1, leukemia virus receptor 1 homolog)

Function

• Na+/phosphate symporter
• housekeeping role in phosphate transport

Kinetic parameters:

• KM=24.1 uM for phosphate;
• Vmax=1.9 nmol/min/mg enzyme

Structure

• region A confers human cells susceptibility to infection animal viruses; substitution of Human SLC20A1 region A by region A of murine SLC20A1 prevents viral infection
• belongs to the pho-4 transporter (TC 2.A.20.-) family

Compartment

membrane

Expression

• ubiquitously expressed
• induced by phosphate deprivation as well as by IL-8 in hypertrophic chondrocytes

Pathology

• may function as a retroviral receptor
• confers human cells susceptibility to infection by:
  • Gibbon Ape Leukemia Virus (GaLV),
  • Simian sarcoma-associated virus (SSAV)
  • Feline leukemia virus subgroup B (FeLV-B)
  • 10A1 murine leukemia virus (10A1 MLV)
• may play a role in extracellular matrix, cartilage, & vascular calcification

More general terms

• solute carrier family 20 (SLC20, SLC20A)
• transmembrane 10 protein
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6574
• OMIM: https://mirror.omim.org/entry/137570
• UniProt: http://www.uniprot.org/uniprot/Q8WUM9.html