forkhead box protein E1; forkhead-related protein 15; drosophila forkhead homolog-like 15; thyroid transcription factor 2; forkhead box protein E2; HNF-3/fork head-like protein 5 (FOXE1, HFKL5, HFKH4, FOXE2)

Function

• transcription factor with role inthyroid gland organogenesis (putative)
• phosphorylated

Structure

contains 1 fork-head DNA-binding domain

Compartment

nucleus

Expression

• detected in adult brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, heart, colon, small intestine, testis, thymus

expression strongest in heart & pancreas

Pathology

• defects in FOXE1 are the cause of Bamforth-Lazarus syndrome

Polymorphism

• alanine stretch that varies from 12-17 residues is present can be used as a marker to study role of FOXE1 in cases of thyroid dysgenesis

More general terms

• forkhead family transcription factor
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/602617
• UniProt: http://www.uniprot.org/uniprot/O00358.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2304