mRNA cap guanine-N7 methyltransferase; RG7MT1; mRNA (guanine-N(7)-)-methyltransferase; mRNA cap methyltransferase; hCMT1; hMet; hcm1p (RNMT KIAA0398)

Function

• mRNA capping methyltransferase
• methylates N7 position of the added guanosine to the 5' cap structure of mRNAs
• binds RNA containing 5'-terminal GpppC
• interacts with importin alpha
  • stimulates RNA-binding & methyltransferase activity
• interaction with importin beta
• interacts with elongating form of polymerase 2 & RNGTT

S-adenosyl-L-methionine + G(5')pppR-RNA
    <-->
S-adenosyl-L-homocysteine + m(7)G(5')pppR-RNA

Structure

• belongs to the methyltransferase superfamily, mRNA cap methyltransferase family

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

widely expressed

More general terms

• N-methyltransferase
• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8731
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8731
• OMIM: https://mirror.omim.org/entry/603514
• UniProt: http://www.uniprot.org/uniprot/O43148.html