thioesterase superfamily member 4; carboxyl-terminal modulator protein (THEM4, CTMP)
Jump to navigation
Jump to search
Function
- interacts with AKT1 (enhances &/or inhibits ?)
- phosphorylated
- interacts with & has inhibitory effect on protein kinase B
Compartment
- cell membrane, cell projection, ruffle, cytoplasm
Expression
- expressed predominantly in skeletal muscle, testis, uterus, brain & kidney
Pathology
- down-regulated in glioblastoma or glioma compared to non-neoplastic brain due to promoter hypermethylation
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q5T1C6.html
- ↑ Maira SM, Galetic I, Brazil DP, Kaech S, Ingley E, Thelen M, Hemmings BA. Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane. Science. 2001 Oct 12;294(5541):374-80. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11598301
- ↑ Ono H, Sakoda H, Fujishiro M, Anai M, Kushiyama A, Fukushima Y, Katagiri H, Ogihara T, Oka Y, Kamata H, Horike N, Uchijima Y, Kurihara H, Asano T. Carboxy-terminal modulator protein induces Akt phosphorylation and activation, thereby enhancing antiapoptotic, glycogen synthetic, and glucose uptake pathways. Am J Physiol Cell Physiol. 2007 Nov;293(5):C1576-85. Epub 2007 Jul 5. PMID: https://www.ncbi.nlm.nih.gov/pubmed/17615157