tropomodulin-4; skeletal muscle tropomodulin; Sk-Tmod (TMOD4)

Function

• blocks elongation & depolymerization of actin filaments at the pointed end
• the Tmod/TM complex contributes to formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton
• binds to the N-terminus of tropomyosin & to actin

Structure

belongs to the tropomodulin family

Compartment

cytoplasm, cytoskeleton

Expression

highly expressed in skeletal msucle

More general terms

• tropomodulin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=29765
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:29765
• OMIM: https://mirror.omim.org/entry/605834
• UniProt: http://www.uniprot.org/uniprot/Q9NZQ9.html