tropomodulin-1; erythrocyte tropomodulin; E-Tmod (TMOD1, D9S57E, TMOD)

Function

• blocks elongation & depolymerization of actin filaments at the pointed end
• the Tmod/TM complex contributes to formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton
• may play a role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus
• binds to the N-terminus of isoforms 2/3 of TPM3 & to actin

Structure

belongs to the tropomodulin family

Compartment

cytoplasm, cytoskeleton

Expression

• highly expressed in the erythrocyte, heart & skeletal muscle

More general terms

• tropomodulin

Database

• UniProt: http://www.uniprot.org/uniprot/P28289.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7111
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7111
• OMIM: https://mirror.omim.org/entry/190930