tropomodulin-2; neuronal tropomodulin; N-Tmod (TMOD2, NTMOD)

Function

• blocks elongation & depolymerization of actin filaments at the pointed end
• the Tmod/TM complex contributes to formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (putative)
• binds to the N-terminus of tropomyosin & to actin

Structure

belongs to the tropomodulin family

Compartment

cytoplasm, cytoskeleton (putative)

Expression

neuronal-tissue specific

More general terms

• tropomodulin
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=29767
• OMIM: https://mirror.omim.org/entry/602928
• UniProt: http://www.uniprot.org/uniprot/Q9NZR1.html