amiloride-sensitive Na+ channel subunit beta; epithelial Na+ channel subunit beta; beta-ENaC; ENaCB; SCNEB; nonvoltage-gated Na+ channel 1 subunit beta; beta-NaCH (SCNN1B)

Function

• Na+ permeable non-voltage-sensitive ion channel beta subunit
• phosphorylated on Ser & Thr
• phosphorylated by ERK1 & ERK2
• interacts with the WW domains of NEDD4, NEDD4L, WWP1 & WWP2

Structure

• belongs to the amiloride-sensitive Na+ channel family

Compartment

• apical cell membrane; multi-pass membrane protein
• apical membrane of epithelial cells

Alternative splicing

named isoforms=2 Pathology:

• defects in SCNN1B are associated with:
  • autosomal recessive pseudohypoaldosteronism type 1 (PHA1)
  • Liddle syndrome

More general terms

• transmembrane 2 protein
• amiloride sensitive Na+ channel subunit
• phosphoprotein

Component of

• amiloride-sensitive Na+ channel or lung Na+ channel

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6338
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6338
• OMIM: https://mirror.omim.org/entry/177200
• OMIM: https://mirror.omim.org/entry/264350
• OMIM: https://mirror.omim.org/entry/600760
• UniProt: http://www.uniprot.org/uniprot/P51168.html