CTP synthase 1; CTP synthetase 1; UTP-ammonia ligase 1 (CTPS1)

Function

• catalyzes ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen
• rate-limiting enzyme in synthesis of cytosine nucleotides
• nucleotide biosynthesis, CTP biosynthesis, CTP from UDP: step 2 [final step]

ATP + UTP + NH3  <-->  ADP + phosphate + CTP

Structure

• belongs to the CTP synthase family
• contains 1 type-1 glutamine amidotransferase domain

More general terms

• cytidine triphosphate [CTP] synthase; UTP-NH3 ligase (CTPS)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1503
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1503
• OMIM: https://mirror.omim.org/entry/123860
• UniProt: http://www.uniprot.org/uniprot/P17812.html