tryptophan-2,3-dioxygenase (tryptophan pyrrolase, tryptophanase, tryptophan oxygenase, tryptamin 2,3-dioxygenase, TRPO, TDO2 TDO, TO)

Function

• incorporates oxygen into the indole moiety of tryptophan
• broad specificity towards tryptamine & derivatives including D- & L-tryptophan, 5-hydroxytryptophan & serotonin (putative)
• amino-acid degradation, L-tryptophan degradation via kynurenine pathway
• L-kynurenine from L-tryptophan: step 1/2

L-tryptophan + O2 <-->  N-formyl-L-kynurenine

Cofactor:

• binds 2 heme groups per tetramer
• hemes are protoheme IV (putative)

Structure

• homotetramer (putative)
• belongs to the tryptophan 2,3-dioxygenase family

Expression

found in liver

More general terms

• dioxygenase
• phosphoprotein

Additional terms

• kynurenine pathway

Database

• OMIM: https://mirror.omim.org/entry/191070
• UniProt: http://www.uniprot.org/uniprot/P48775.html