transaldolase (TALDO1, TAL, TALDO, TALDOR)

Function

• carbohydrate degradation, pentose phosphate pathway
• D-fructose 6-phosphate & D-glyceraldehyde 3-phosphate from D-ribose 5-phosphate & D-xylulose 5-phosphate (non-oxidative stage): step 2/3

sedoheptulose 7-phosphate + D-glyceraldehyde-3-phosphate
                      <-->
D-erythrose 4-phosphate + D-fructose 6-phosphate

Structure

belongs to the transaldolase family, type 1 subfamily

Compartment

cytoplasm (probable)

Pathology

• defects in TALDO1 are the cause of transaldolase 1 deficiency

More general terms

• transferase
• phosphoprotein

Additional terms

• hexose monophosphate shunt, pentose phosphate pathway or phosphogluconate shunt

Database

• OMIM: https://mirror.omim.org/entry/602063
• OMIM: https://mirror.omim.org/entry/606003
• UniProt: http://www.uniprot.org/uniprot/P37837.html