myosin heavy chain 15 (MYH15, KIAA1000)

Function

• myosin heavy chain
• muscle contraction

Structure

• myosin is a hexameric protein that consists of
  • 2 myosin heavy chain subunits
  • 2 myosin essential light chain subunits
  • 2 myosin regulatory light chain subunits
• each myosin heavy chain can be split into 1 light meromyosin & 1 heavy meromyosin; it can later be split further into 2 globular subfragments (S1) & 1 rod-shaped subfragment (S2)
• rodlike tail sequence is highly repetitive 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils
• contains 1 myosin head-like domain

Compartment

thick filaments of the myofibrils

More general terms

• myosin heavy chain
• phosphoprotein

Additional terms

• myosin
• myosin-15; unconventional myosin-15 (MYO15A, MYO15)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=22989
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:22989
• OMIM: https://mirror.omim.org/entry/609929
• UniProt: http://www.uniprot.org/uniprot/Q9Y2K3.html