phosphorylase B kinase alpha-M (PHKA1, skeletal muscle isoform)

Function

• enzyme regulatory subunit of phosphorylase kinase

Structure

• belongs to the phosphorylase kinase regulatory chain family

Compartment

cell membrane; lipid-anchor; cytoplasmic side

Alternative splicing

named isoforms=2

Expression

• muscle specific
• isoform 1 is predominant in vastus lateralis muscle
• isoform 2 predominates slightly in heart, & it predominates clearly in the other tissues tested

Pathology

• defects in PHKA1 are the cause of glycogen storage disease type 9D

More general terms

• phosphorylase kinase-alpha
• phosphoprotein
• prenyl protein

Component of

• phosphorylase kinase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5255
• OMIM: https://mirror.omim.org/entry/311870
• UniProt: http://www.uniprot.org/uniprot/P46020.html