DNA polymerase alpha 70 kD subunit (POLA2, DNA polymerase subunit alpha B)
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Function
- may play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery
- binds to POLA1 (catalytic subunit)
- phosphorylated in a cell cycle-dependent manner, in G2/M phase
Structure
- N-terminal 240 amino acids are sufficient to mediate complex formation
- belongs to the DNA polymerase alpha subunit B family
Compartment
More general terms
Component of
References
- ↑ Linn S How many pols does it take to replicate nuclear DNA? Cell 66:185 1991 PMID: https://www.ncbi.nlm.nih.gov/pubmed/1855251
- ↑ UniProt http://www.uniprot.org/uniprot/Q14181.html