proteasome activator complex subunit 4 (proteasome activator PA200, PSME4, KIAA0077)

Function

• activates proteasomal cleavage of peptides (energy- independent)
• role in spermatogenesis (putative)
• role in DNA repair (putative)
• interacts with the 20S & 26S proteasomes
• phosphorylated

Structure

• homodimer
• contains 6 HEAT repeats

Compartment

• nucleus, nuclear speckle
• found in nuclear foci following treatment with ionizing radiation, but not with ultraviolet irradiation or H2O2

Alternative splicing

named isoforms=4

More general terms

• protein subunit
• nuclear protein
• phosphoprotein

Component of

• proteasome activator complex (PAC)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2319
• OMIM: https://mirror.omim.org/entry/607705
• UniProt: http://www.uniprot.org/uniprot/Q14997.html