eukaryotic initiation factor 3 subunit 12 (eukaryotic translation initiation factor 3 subunit K, eIF-3 p25, eIF-3 p28, eIF3k, muscle specific gene M9 protein, PLAC-24, EIF3S12, ARG134, HSPC029, MSTP001, PTD001)

Function

• binds to the 40S ribosome & promotes the binding of methionyl-tRNAi & mRNA
• interacts with EIF3C, EIF3G & EIF3J
• interacts with CCND3, but not with CCND1 & CCND2

Structure

• N-terminus is blocked
• belongs to the eIF-3 subunit K family

Compartment

nucleus, cytoplasm

Expression

• ubiquitous
• highest levels of expression in brain, testis & kidney

More general terms

• eukaryotic initiation factor subunit
• phosphoprotein

Component of

• eukaryotic initiation factor 3; ribosome dissociation factor (eIF3)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2733
• UniProt: http://www.uniprot.org/uniprot/Q9UBQ5.html