26S proteasome regulatory subunit S2 (26S proteasome subunit p97, TNF type 1 receptor associated protein 2, 55.11 protein, PSMD2, TRAP2)

Function

• regulatory subunit of the 26S proteasome
• binds to the intracellular domain of TNF receptor-1 (TNFR1)
• the binding domain of TRAP1 & TRAP2 resides outside the death domain of TNFR1

Structure

• belongs to the proteasome subunit S2 family
• contains 7 PC repeats

Expression

• found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung & placenta

More general terms

• 26S proteasome subunit
• phosphoprotein

Component of

• 19S proteasome (PA700 complex)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5708
• OMIM: https://mirror.omim.org/entry/606223
• UniProt: http://www.uniprot.org/uniprot/Q13200.html