dimethylarginine dimethylaminohydrolase 1 (NG,NG-dimethylarginine dimethylaminohydrolase 1, dimethylargininase-1, DDAHI, DDAH-1, DDAH1, DDAH)

Function

• hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) & N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of nitric oxide synthase (NOS)
• nitric oxide generation.

Cofactor: binds 1 Zn+2

More general terms

• hydrolase
• metalloprotein

Database

• OMIM: https://mirror.omim.org/entry/604743
• UniProt: http://www.uniprot.org/uniprot/O94760.html