protein SCO1 homolog, mitochondrial (SCO1, SCOD1)

Function

• thought to play a role in cellular copper homeostasis, mitochondrial redox signaling or insertion of copper into the active site of COX

Structure

• homodimer
• belongs to the SCO1/2 family

Compartment

mitochondria

Expression

• predominantly expressed in tissues characterized by high rates of oxidative phosphorylation. i.e.
  • muscle
  • heart
  • brain

Pathology

• defects in SCO1 are a cause of cytochrome c oxidase deficiency

More general terms

• mitochondrial protein
• metalloprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6341
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6341
• OMIM: https://mirror.omim.org/entry/220110
• OMIM: https://mirror.omim.org/entry/603644
• UniProt: http://www.uniprot.org/uniprot/O75880.html