Queuine tRNA-ribosyltransferase; guanine insertion enzyme; tRNA-guanine transglycosylase (QTRT1, TGT, TGUT)

Function

• interacts with QTRTD1 to form an active queuine tRNA-ribosyltransferase
• exchanges queuine for guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His & -Tyr), thus forming the hypermodified nucleoside queuosine
• tRNA modification; tRNA-queuosine biosynthesis
• interacts with QTRTD1 (putative)

Cofactor: binds 1 Zn+2 per subunit (putative)

Structure

• belongs to the queuine tRNA-ribosyltransferase family

Compartment

• cytoplasm (putative)
• mitochondria
• nucleus (putative)
• weakly associates with mitochondria, possibly via QTRTD1

More general terms

• transferase
• metalloprotein

Additional terms

• queuine

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=81890
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:81890
• OMIM: https://mirror.omim.org/entry/609615
• UniProt: http://www.uniprot.org/uniprot/Q9BXR0.html