carboxypeptidase M (CPM)

Function

• specifically removes C-terminal basic residues (Arg or Lys) from peptides & proteins
• role in the control of peptide hormone & growth factor activity at the cell surface, & in the membrane-localized degradation of extracellular proteins (putative)

Cofactor: binds 1 Zn+2 per subunit

Structure

belongs to the peptidase M14 family

Compartment

cell membrane, lipid-anchor, GPI-anchor

More general terms

• carboxypeptidase
• glypiated protein
• metalloprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1368
• UniProt: http://www.uniprot.org/uniprot/P14384.html
• OMIM: https://mirror.omim.org/entry/114860
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1368