GTPase RhebL1 (Ras homolog enriched in brain-like protein 1, Rheb-like protein 1, Rheb2, Ras homolog enriched in brain like-1 c, RhebL1c, RHEBL1)

Function

• binds GTP & exhibits intrinsic GTPase activity
• may activate NF-kappa-B-mediated gene transcription
• promotes signal transduction through FRAP1, activates RPS6KB1, & is a downstream target of the small GTPase-activating proteins TSC1 & TSC2
• interacts with FRAP1

Structure

belongs to the small GTPase superfamily. Rheb family

Compartment

• cell membrane; lipid-anchor; cytoplasmic side (putative)

Alternative splicing

named isoforms=2

Expression

ubiquitously expressed

Pathology

• expression increased at least 2-fold in several tumor cell lines

More general terms

• guanosine triphosphatase (GTPase)
• prenyl protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1212
• UniProt: http://www.uniprot.org/uniprot/Q8TAI7.html