3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial

Function

• fatty acid biosynthesis
• role in the biosynthesis of lipoic acid
• role in biosynthesis of longer chain fatty acids required for mitochondrial function

Acyl-[acyl-carrier-protein] + malonyl-[acyl- carrier-protein] <--> 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein]

Inhibition:

• inhibited by cerulenin

Kinetic parameters:

• KM=1.8 uM for C10-[acyl-carrier-protein];
• Vmax=364 nmol/min/mg enzyme toward C10-[acyl-carrier-protein];
• highest catalytic efficiency is observed for C10-[acyl-carrier-protein]

Structure

• belongs to the beta-ketoacyl-ACP synthases family

Compartment

mitochondrion

Expression

• widely expressed
  • higher expression in heart, skeletal muscle, liver & kidney which contain high levels of active mitochondria

More general terms

• acyltransferase
• mitochondrial protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9NWU1.html