glycine N-acyltransferase (acyl-CoA:glycine N-acyltransferase, AAc, aralkyl acyl-CoA N-acyltransferase, aralkyl acyl-CoA:amino acid N-acyltransferase, HRP-1[CLP], GLYAT, ACGNAT, CAT, GAT)

Function

• mitochondrial acyltransferase
• transfers acyl group to N-terminus of glycine
• can conjugate a multitude of substrates to form a variety of N-acylglycines

Acyl-CoA + glycine <--> CoA + N-acylglycine

Kinetic parameters:

• KM=57.9 mM for benzoyl CoA
• KM=83.7 mM for salicyl CoA
• KM=124 mM for isovaleryl CoA
• KM=198 mM for octanoyl CoA;
• Vmax=17.1 umol/min/mg enzyme with benzoyl CoA as substrate
• Vmax=10.1 umol/min/mg enzyme with salicyl CoA as substrate
• Vmax=7.64 umol/min/mg enzyme with isovaleryl CoA as substrate
• Vmax=3.3 umol/min/mg enzyme with octanoyl CoA as substrate

Structure

belongs to the glycine N-acyltransferase family

Compartment

mitochondrion

Alternative splicing

named isoforms=2

More general terms

• acyltransferase
• mitochondrial protein

Database

• OMIM: https://mirror.omim.org/entry/607424
• UniProt: http://www.uniprot.org/uniprot/Q6IB77.html