acyl-coenzyme A synthetase ACSM3, mitochondrial (acyl-CoA synthetase medium-chain family member 3, middle-chain acyl-CoA synthetase 3, butyrate-CoA ligase 3, butyryl coenzyme A synthetase 3, protein SA homolog, ACSM3, SAH)

Function

• medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro)
• acts on acids from C(4) to C(11) & on the corresponding 3-hydroxy- & 2,3- or 3,4- unsaturated acids (in vitro)

ATP + an acid + CoA <--> AMP + diphosphate + acyl-CoA

Cofactor: Mg+2 (putative)

Structure

• belongs to the ATP-dependent AMP-binding enzyme family

Compartment

mitochondrial matrix (putative)

Alternative splicing

named isoforms=2

Notes

uncertain whether Met-1 or Met-9 is the initiator

More general terms

• acyl coenzyme-A [CoA] synthetase or acyl coenzyme-A [CoA] ligase
• mitochondrial protein

Database

• OMIM: https://mirror.omim.org/entry/145505
• UniProt: http://www.uniprot.org/uniprot/Q53FZ2.html