cardiolipin synthase; CLS; protein GCD10 homolog (CRLS1, C20orf155, CLS1)

Function

• catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin, diphosphatidylglycerol & glycerol

2 Phosphatidylglycerol  <-->  diphosphatidylglycerol + glycerol

Structure

• belongs to the CDP-alcohol phosphatidyltransferase class-I family

Compartment

mitochondrial inner membrane

Expression

expressed in heart, skeletal muscle, liver

More general terms

• transferase
• mitochondrial protein
• transmembrane 5 protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54675
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:54675
• OMIM: https://mirror.omim.org/entry/608188
• UniProt: http://www.uniprot.org/uniprot/Q9UJA2.html