cytochrome C heme lyase; holocytochrome c synthase (HCCS, CCHL)

Function

• links covalently the heme group to the apoprotein of cytochrome c (putative)

holocytochrome c <--> apocytochrome c + heme

Structure

• belongs to the cytochrome c-type heme lyase family
• contains 2 HRM (heme regulatory motif) repeats

Compartment

mitochondrial inner membrane (putative)

Pathology

• defects in HCCS are a cause of syndromic microphthalmia 7

More general terms

• lyase
• mitochondrial protein

Database

• UniProt: http://www.uniprot.org/uniprot/P53701.html
• OMIM: https://mirror.omim.org/entry/300056
• OMIM: https://mirror.omim.org/entry/309801