short chain enoyl CoA hydratase (SCEH, ECHS1)

Function

• straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate
• fatty acid beta-oxidation cycle; step 2

(3S)-3-hydroxyacyl-CoA <--> trans-2(or 3)-enoyl-CoA + H2O

Structure

• homohexamer; dimer of trimers (putative)
• belongs to the enoyl-CoA hydratase/isomerase family

Compartment

mitochondrial matrix

Expression

• expressed in liver, fibroblast, muscle
• barely detectable in spleen & kidney

More general terms

• enol CoA hydratase
• mitochondrial protein

Database

• OMIM: https://mirror.omim.org/entry/602292
• UniProt: http://www.uniprot.org/uniprot/P30084.html