pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial (PDPr, PDPR, KIAA1990)

Function

• decreases the sensitivity of PDP1 to Mg+2; inhibition is reversed by the polyamine spermine
• heterodimer of a catalytic (PDP1) & a regulatory (PDPR) subunit (putative)

Structure

belongs to the gcvT family

Compartment

mitochondrial matrix (putative)

Notes

uncertain whether Met-1 or Met-2 is the initiator

More general terms

• mitochondrial protein
• protein subunit

Component of

• pyruvate dehydrogenase phosphatase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5506
• UniProt: http://www.uniprot.org/uniprot/Q8NCN5.html