centrosomal protein of 72 kD; Cep72 protein (CEP72, KIAA1519)

Function

• role in the recruitment of key centrosomal proteins to the centrosome
• provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs)
• role in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids
• required for localization of KIZ/PLK1S1, AKAP9 & gamma-tubulin ring complexes (gamma-TuRCs)
• interacts with KIZ/PLK1S1

Structure

• belongs to the CEP72 family
• contains 3 LRR repeats (leucine-rich repeats)
• contains 1 LRRCT domain

Compartment

• cytoplasm, cytoskeleton, centrosome
• localizes to the centrosome & centrosome-surrounding particles throughout the cell cycler
• localization may be microtubule-dependent

Alternative splicing

named isoforms=2

More general terms

• centrosomal protein
• leucine-rich repeat-containing protein (LRRC)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55722
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55722
• UniProt: http://www.uniprot.org/uniprot/Q9P209.html