centrosomal protein of 76 kD (CEP76, C18orf9)

Function

• centrosomal protein
• role in regulation of centriole duplication
• required to limit centriole duplication to once per cell cycle by preventing centriole reduplication
• interacts with CEP110/CP110 & CEP97

Structure

belongs to the CEP76 family

Compartment

• cytoplasm, cytoskeleton, centrosome, centriole
• does not localize along the ciliary axoneme

Alternative splicing

named isoforms=3

Expression

• expressed at low level in G1 phase & is induced in S phase & G2 phase, during which point centrioles have already commenced duplication (at protein level)

More general terms

• centrosomal protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=79959
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:79959
• UniProt: http://www.uniprot.org/uniprot/Q8TAP6.html