inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 8 (USP17L8)

Structure

• belongs to the peptidase C19 family, USP17 subfamily

probably inactive as an hydrolase due to the lack of catalytic His at position 334

Compartment

nucleus (putative)

Notes

• the RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copy of USP17
• it is present with an interindividual variation in copy number & between 20 to 103 copies can be found in the genome both on chromosome 4 & chromosome 8

More general terms

• ubiquitin C-terminal hydrolase
• nuclear protein

Database

• UniProt: http://www.uniprot.org/uniprot/P0C7I0.html