rRNA/tRNA 2'-O-methyltransferase fibrillarin-like (FBLL1)

Function

• role in pre-rRNA processing
• utilizes methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA

Structure

• belongs to the fibrillarin family
• by homology to other fibrillarins, some or all of the N-terminal domain arginines are modified to asymmetric dimethylarginine (DMA)

Compartment

• nucleus, nucleolus
• fibrillar region of the nucleolus (putative)

More general terms

• methyltransferase
• nuclear protein

Database

• UniProt: http://www.uniprot.org/uniprot/A6NHQ2.html