interferon-stimulated 20 kD exonuclease-like 1 (apoptosis enhancing nuclease, ISG20L1, AEN, SBBI58)

Function

• may contribute to radiation response during ionizing radiation induced apoptosis by cooperatively cleaving DNA substrates along with other apoptotic nucleases & ehance apoptosis

Structure

contains 1 exonuclease domain

Compartment

• nucleus
• pronounced perinuclear localization at 1 hour after post-irradiation

Alternative splicing

named isoforms=2

Expression

induced by ionizing radiation

More general terms

• exonuclease
• nuclear protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6478
• UniProt: http://www.uniprot.org/uniprot/Q8WTP8.html