Proteasome assembly chaperone 2 (PAC-2, tumor necrosis factor superfamily member 5-induced protein 1, hepatocellular carcinoma-susceptibility protein 3, PSMG2, HCCA3, PAC2, TNFSF5IP1)

Function

• chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1
• the PSMG1-PSMG2 heterodimer binds to the PSMA5 & PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring & prevents alpha ring dimerization
• forms a heterodimer with PSMG1
• the PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 & PSMA7 proteasome alpha subunits
• degraded by the proteasome upon completion of 20S proteasome maturation

Structure

belongs to the PSMG2 family

Compartment

nucleus (putative)

Expression

• widely expressed
• expressed in lung, brain & colon > muscle, stomach, spleen & heart > small intestine, pancreas & liver.

Pathology

• highly expressed in hepatocellular carcinomas with low levels in surrounding liver tissue

More general terms

• nuclear protein
• chaperonin; chaperone

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5698
• UniProt: http://www.uniprot.org/uniprot/Q969U7.html