Chromosome-associated kinesin KIF4B (chromokinesin-B, KIF4B)

Function

• motor protein
• translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone & midbody & for successful cytokinesis.
• may play a role in mitotic chromosomal positioning & bipolar spindle stabilization

Structure

• belongs to the kinesin-like protein family, homokinesin subfamily
• contains 1 kinesin-motor domain

Compartment

nucleus matrix (putative)

Expression

specifically expressed in testis

More general terms

• nuclear protein
• microtubule-associated protein (MAP)

Database

• UniProt: http://www.uniprot.org/uniprot/Q2VIQ3.html