neuron navigator 3 (steerin-3, pore membrane &/or filament-interacting-like protein 1, Unc-53 homolog 3, unc53H3, NAV3, KIAA0938, POMFIL1, STEERIN3)

Function

• may regulate IL2 production by T-cells
• may be involved in neuron regeneration

Structure

contains 1 CH domain (calponin-homology domain)

Compartment

nucleus outer membrane

Alternative splicing

named isoforms=3

Expression

• highly expressed in brain
• expressed at low levels in heart & placenta
• present in activated T-cells but not in resting T-cells
• expressed in fetal brain

Pathology

• down-regulated in primary neuroblastoma
• defects in NAV3 may be a cause of mycosis fungoides Sezary syndrome

More general terms

• nuclear protein

Database

• OMIM: https://mirror.omim.org/entry/254400
• UniProt: http://www.uniprot.org/uniprot/Q8IVL0.html