nuclear body protein SP140 (nuclear autoantigen Sp-140, speckled 140 kD, LYSp100 protein, lymphoid-restricted homolog of Sp100, SP140, LYSP100)

Function

• component of the nuclear body
• induced by interferons

Structure

• contains 1 bromo domain
• contains 1 PHD-type zinc finger
• contains 1 SAND domain

Compartment

• nucleus, cytoplasm
• localized to nuclear structures termed LANDS

Alternative splicing

named isoforms=3

Expression

• expressed in spleen & peripheral blood leukocytes > thymus, prostate, ovary, small intestine, colon > heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas

Pathology

• role in pathogenesis of acute promyelocytic leukemia & viral infection
• antigen is recognized by autoantibodies from patients with primary biliary cirrhosis

More general terms

• nuclear protein
• zinc finger protein

Database

• OMIM: https://mirror.omim.org/entry/608602
• UniProt: http://www.uniprot.org/uniprot/Q13342.html