PCNA-associated factor; hepatitis C virus NS5A-transactivated protein 9; HCV NS5A-transactivated protein 9; overexpressed in anaplastic thyroid carcinoma 1; OEATC-1; p15PAF (KIAA0101, NS5ATP9, PAF, L5)

Function

• protection of cells from UV-induced cell death
• interacts with PCNA & isoform 2/p33ING1b of ING1
• UV irradiation enhances interaction with PCNA & increases nuclear localization

Compartment

nucleus, mitochondrion

Expression

• expressed predominantly in liver, pancreas, placenta
• not detected in heart, brain
• induced by UV irradiation

Pathology

• highly expressed in a number of tumors
  • esophageal tumors
  • anaplastic thyroid carcinoma
  • non-small-cell lung cancer lines

More general terms

• nuclear protein
• phosphoprotein

Additional terms

• proliferating cell nuclear antigen (PCNA)

Database

• UniProt: http://www.uniprot.org/uniprot/Q15004.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9768
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9768
• OMIM: https://mirror.omim.org/entry/610696
• UniProt: http://www.uniprot.org/uniprot/Q15004.html