PHD finger protein 1; protein PHF1; polycomb-like protein 1; hPCl1 (PHF1, PCL1)

Function

• transcriptional repressor
• may promote methylation of histone H3 on Lys-27 by the PRC2/EED-EZH2 complex
• interacts with CHMP1 (putative)
• interacts with the PRC2 complex
• phosphorylated on Ser-360

Structure

contains 2 PHD-type Zn+2 fingers

Compartment

• nucleus. cytoplasm, cytoskeleton, centrosome
• localizes specifically to the promoters of numerous target genes
• colocalizes with NEK6 in the centrosome

Alternative splicing

named isoforms=2

Expression

• highest expression in heart, skeletal muscle, & pancreas
• lower expression in brain, placenta, lung, liver & kidney

More general terms

• PHD finger protein
• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5252
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5252
• OMIM: https://mirror.omim.org/entry/602881
• UniProt: http://www.uniprot.org/uniprot/O43189.html