histone-lysine N-methyltransferase SETDB2; chronic lymphocytic leukemia deletion region gene 8 protein; lysine N-methyltransferase 1F; SET domain bifurcated 2 (SETDB2, C13orf4, CLLD8 KMT1F)

Function

• histone methyltransferase
• methylates Lys-9 of histone H3

Structure

• belongs to the histone-lysine methyltransferase family
• contains 1 MBD (methyl-CpG-binding) domain
• contains 1 pre-SET domain
• contains 1 SET domain

Compartment

nucleus

Expression

• ubiquitous
• highest expression in heart, testis, ovary

More general terms

• histone N-methyltransferase
• zinc finger protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=83852
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:83852
• OMIM: https://mirror.omim.org/entry/607865
• UniProt: http://www.uniprot.org/uniprot/Q96T68.html